Expert Fabry en Suisse du Nord

PD Dr. med. Albina Nowak-Wilhelm

Klinik für Endokrinologie, Diabetologie und Klinische Ernährung
Universitätsspital Zürich
Rämistrasse 100
8091 Zürich
Tel.: +41 (0)44 255 36 20
Internistischer Dienst
Psychiatrische Universitätsklinik Zürich
Lenggstrasse 31, Postfach
8032 Zürich
Tel.: +41 (0)44 384 23 21


12/2017 Habilitation “Rare inherited diseases with multiorgan involvement in adults. Fabry Disease as an example».
Since 02/2017 Advanced Studies for Master Degree in Pharmaceutical Medicine Clinical Trials Center USZ and University Basel
2015 Course of Descriptive Biostatistics and Regression Analysis with exercises, passed exam and achievement of European Credit Transfer and Accumulation System (ECTS) point; University of Zurich, Institute for Epidemiology, Biostatistics and Prevention
2014 Attendant Elective „Scientific writing“ at the University of Zurich
1999-2003 Scientific research fellow, establishing and leading the Living Organ Donors Registry; Doctoral Thesis “Long-term consequences of living kidney donation with distinction “magna cum laude”, Department of Nephrology, University Hospital Frankfurt, Germany
1997-2003 Medical School Universities of Frankfurt am Main and Rostock, Germany, King`s College London; degree – outstanding; final written exam with ranking among the best 0.3% in Germany
1993-1997 Attending Night High School Diploma (Abendmatura), Villingen-Schwenningen, Germany. Price for outstanding achievements in Natural Sciences. On parallel, full-time occupation as nephrology nurse
1995 Eduction as Speciality Nurse for Nephrology and Dialysis, Price for the best passed exams, University Hospital Ulm, Germany
1990-1993 General Nurse School Oberndorf a. N., Germany


Since 07/2018 Senior Consultant (Oberärztin), Department of Endocrinology and Clinical Nutrition, UHZ: 50%
Since 01/2018 Head Physician (Chefärztin), Internal Medicine, University Hospital of Psychiatry Zurich: 50%
01/2018-07/2018 Senior Researcher and Lecturer Cardiology Department UHZ
10/2010-01/2018 Senior Consultant (Oberärztin), Department of Internal Medicine, UHZ
07/2008-11/2010 Senior House Officer, Department of Internal Medicine; Speciality Registrar, Division of Nephrology University Hospital Basel
04/2009-10/2009 Registrar Intensive Care Unit, Royal Sussex County Hospital Brighton, UK: Exchange program via Basel University
07/2007-06/2008 Senior House Officer, Department of Internal Medicine Spitalzentrum Biel
04/2004-04/2007 Senior House Officer, Department of Internal Medicine Speciality; Registrar Department of Nephrology University Hospital Bern
1993-1997 Nurse as a full time job, Department of Nephrology and Hemodialysis Villingen-Schwenningen, Germany.
On parallel, High School Diploma (matura), after 6pm.


  • Leading specialized consultation in storage disorders. Focus on Fabry Disease and other rare inborn Disorders. Clinical and research work, supervision of young doctors, teaching of medical students, treatment of out- und inpatients.


    • Since November 2010, regular teaching of medical students University of Zurich in the 2nd and 3rd years Bachelor BMed as well as 1st and 3rd years MMed.

Adhésions et participation aux conseils et aux panels

    • Swiss Society of General Internal Medicine
    • Swiss Society of Nephrology
    • Swiss Society of Hypertension
    • Swiss Group for Inborn Errors of Metabolism
    • Medical Board of Fabry Suisse and Lysosuisse (patients`organisation)
    • Lead of multidisciplinary Fabry Boards, taking place at USZ three-monthly
    • European Board of Fabry Registry

Honneurs, prix

23/11/2017 Hemmi-Price for the Project Effect of intravenous iron versus placebo on cerebral dopamine receptor density in non-anemic premenopausal women with low ferritin levels and fatigue.
03/2017 First best poster at the International Fabry Experts Meeting Berlin “Long-term outcome of kidney transplantation in Fabry disease”
03/2017 Second best poster at the International Fabry Experts Meeting Berlin “Phenotype, Disease Severity and Genotype Reflected by Serum LysoGb3 Levels in Patients with Fabry Disease”
2012 First Price of the Swiss Society of Internal Medicine for publication “Direct comparison of three natriuretic peptides for prediction of short- and long-term mortality in patients with community-acquired pneumonia”


  • German
  • English
  • Russisch



  1. Gossmann J, Wilhelm A, Kachel H. G., Jordan J, Sann U, Geiger H, Kramer W, Scheuermann EH
    Long-term consequences of live kidney donation follow-up in 93% of living kidney donors in a single transplant center
    Am J Transplant. 2005;5(10):2417-24
  2. Hamscho N, Wilhelm A, Döbert N, Menzel C, Gossmann J, Berner U, Zaplatnikov K, Scheuermann EH, Grünwald F
    Residual kidney function after donor nephrectomy. Assessment by 99mTc-MAG3-clearance
    Nuklearmedizin. 2005;44(5):200-4
  3. Jordan J, Sann U, Janton A, Gossmann J, Kramer W, Kachel HG, Wilhelm A, Scheuermann EH
    Living kidney donors’ long-term psychological status and health behavior after nephrectomy – a retrospective study
    J Nephrol. 2004;17(5):728-35
  4. Hofmann L, Simon-Zoula S, Nowak A, Giger A, Vock P, Boesch C, Frey F, Vogt B.
    BOLD-MRI for the assessment of renal oxygenation in humans: Acute effect of nephrotoxic xenobiotics
    Kidney Int. 70(1):144-50
  5. Sollinger D, Mohaupt MG, Wilhelm A, Uehlinger D, Frey FJ, Eisenberger U
    Arterial stiffness assessed by digital volume pulse correlates with comorbidity in patients with ESRD
    Am J Kidney Dis. 2006;48(3):456-63
  6. Breidthardt T, Socrates T, Noveanu M, Klima T, Heinisch C, Reichlin T, Potocki M, Nowak A, Tschung C, Arenja N, Bingisser R, Mueller C.
    Impact and Clinical Prediction of Worsening Renal Function in Acute Decompensated Heart Failure
    Am J Cardiol. 2011;107(5):730-5
  7. Nowak A, Breidthardt T, Christ-Crain M, Bingisser R, Meune C, Tanglay Y, Heinisch C, Reiter M, Drexler B, Arenja N, Twerenbold R, Stolz D, Tamm M, Müller B, Müller C
    Direct Comparison of Three Natriuretic Peptides for Prediction of Short- and Long-term Mortality in Patients With Community-Acquired Pneumonia
    Chest. 2012;141(4):974-82.
  8. Nowak A, Breidthardt T, Dejung S, Christ-Crain M, Bingisser R, Drexler B, Meune C, Marono D, Mosimann T, Müller B, Müller C
    Natriuretic Peptides for early prediction of acute kidney injury in community acquired pneumonia
    Clinica Chimica Acta, 2013 Apr 18;419:67-72
  9. Artunc F, Nowak A, Mueller C, Breidthardt T, Twerenbold R, Wagner R, Friedrich B
    Plasma concentrations of the vasoactive peptides mid-regional pro-adrenomedullin, copeptin and c-terminal pro-endothelin 1 in hemodialysis patients: associated factors and prediction of mortality
    PLoS One. 2014 Jan 22;9(1):e86148
  10. Fauchère I, Moormann D, Maier W, Altweg L, Lüscher T, Grünenfelder J, Nowak A, Tüller D, Genoni M, Falk V, Hermann M
    Rehabilitation After TAVI Compared To Surgical Aortic Valve Replacement
    Int J Cardiol. 2014 May 15;173(3):564-6
  11. Nowak A, Friedrich B, Artunc F, Serra AL, Breidthardt T, Twerenbold R, Peter M, Potocki M, Mueller C
    Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients
    PLoS One. 2014 Jul 3;9(7):e100688
  12. Muskalla AM, Suter PM, Saur M, Nowak A, Hersberger M, Krayenbuehl PA
    G-Protein Receptor Kinase 4 Polymorphism and Response to Antihypertensive Therapy
    Clin Chem. 2014 Dec;60(12):1543-8
  13. Artunc F, Nowak A, Müller C, Peter A, Heyne N, Häring H-U, Friedrich B
    Mortality prediction using modern peptide biomarkers in hemodialysis patients – a comparative analysis
    Kidney Blood Press Res. 2014 Dec 15;39(6):563-572
  14. Nowak A, Artunc F, Serra A, Müller C, Pollock E, Krayenbuehl P-A, Friedrich B
    Sclerostin and other circulating bone remodeling markers in hemodialysis patients
    Kidney Blood Press Res. 2015;40(3):266-76
  15. Weidmann ZM, Breidthardt T, Twerenbold R, Züsli C, Nowak A, von Eckardstein A, Erne P, Rentsch K, de Oliveira MT Jr, Gualandro D, Maeder MT, Rubini Gimenez M, Pershyna K, Stallone F, Haas L, Jaeger C, Wildi K, Puelacher C, Honegger U, Wagener M, Wittmer S, Schumacher C, Krivoshei L, Hillinger P, Osswald S, Mueller C
    Prediction of mortality using quantification of renal function in acute heart failure
    Int J Cardiol.. 2015 Dec 15;201:650-7
  16. Schmied C, Nowak A, Gruner C, Olinger E, Debaix H, Brauchlin A, Frank M, Reidt S, Monney P, Barbey F, Shah D, Namdar M
    The value of ECG parameters as markers of treatment response in Fabry cardiomyopathy
    Heart. 2016 Aug 15;102(16):1309-14
  17. Nowak A, Mechtler TP, Desnick RJ, Kasper DC
    Plasma LysoGb3: A useful biomarker for the diagnosis and treatment of Fabry disease heterozygotes
    Mol Genet Metab. 2017 Jan – Feb;120(1-2):57-61
  18. Nowak A, Boesch L, Andres E, Battegay E, Hornemann T, Schmid C, Bischoff-Ferrari H, Suter P, Krayenbuehl P-A
    Effect of vitamin D3 on self-perceived fatigue: a double-blind randomized placebo-controlled trial.
    Medicine, (Baltimore). 2016 Dec;95(52):e5353
  19. Nowak A, Koch G, Huynh-Do U, Siegenthaler M, Marti H-P, Pfister M
    Disease progression modeling to evaluate the effects of enzyme replacement therapy on kidney function in adult patients with the Classic phenotype of Fabry disease.
    Kidney Blood Press Res. 2017;42(1):1-15.
  20. Menghini M, Prünte Ch, Krayenbuehl PA, Nowak A
    Assessment of drusen and other retinal degenerative changes in patients with hereditary hemochromatosis
    Retina. 0:1–6, 2017
    21. Saleh L, Tang J, Gawinecka J, Boesch L, Fraser WD, von Eckardstein A, Nowak A
    Impact of a single oral dose of 100,000 IU vitamin D3 on vitamin D metabolite profiles in healthy adults with vitamin D insufficiency
    Clin Chem Lab Med. 2017 Mar 22 [Epub ahead of print]
  21. Saleh L, Tang J, Gawinecka J, Boesch L, Fraser WD, von Eckardstein A, Nowak A
    Impact of a single oral dose of 100,000 IU vitamin D3 on vitamin D metabolite profiles in healthy adults with vitamin D insufficiency
    Clin Chem Lab Med. 2017 Mar 22 [Epub ahead of print]
  22. Nowak A, Mechtler TP, Kasper DC, Desnick RJ
    Correlation of Lyso-Gb3 levels in Dried Blood Spots and Sera from patients with Classic and Later-Onset Fabry Disease
    Mol Genet Metab. 2017 Aug;121(4):320-324
  23. Nowak A, Franzen DP, Haile SR, Mottet D, Bonani M, Kohler M, Krayenbuehl PA, Barbey F
    Long-term follow-up of pulmonary function in Fabry disease: a multi-center observational study
    PLoS One. 2017 Jul 25;12(7):e0180437
  24. Lenders M, Oder D, Nowak A, Canaan-Kühl S, Arash-Kaps L, Drechsler C, Schmitz B, Nordbeck P, Hennermann JB, Kampmann C, Reuter S, Brand SM, Wanner C, Brand E.
    Impact of immunosuppressive therapy on therapy-neutralizing antibodies in transplanted patients with Fabry disease.
    J Intern Med. 2017 Sep;282(3):241-253
  25. Siegenthaler M, U. Huynh-Do U, Krayenbuehl P, Pollock E, Widmer U, Debaix H, Olinger E, Frank M, Namdar M, Ruschitzka F, Nowak A
    Impact of Cardio-Renal Syndrome on adverse outcomes in patients with Fabry disease in a long-term follow-up
    International Journal of Cardiology, in press
  26. Annema W, Nowak A, von Eckardstein A, Saleh L
    Evaluation of the new restandardized Abbott Architect 25-OH Vitamin D assay in vitamin D-insufficient and vitamin D-supplemented individuals
    J Clin Lab Anal. 2017 Sep 19 doi: 10.1002/jcla.22328. [Epub ahead of print]
  27. Nowak A, Mechtler TP, Hornemann T, Gawinecka J, Theswet E, Hilz MJ, Kasper DC
    Genotype, phenotype and disease severity reflected by serum LysoGb3 levels in patients with Fabry disease
    Mol Genet Metab. 2017 Jul 5. pii: S1096-7192(17)30328-1 in press


  1. Göksu Y, Hofbauer G, Serra AL, Nowak A
    Maligne Hauterkrankungen bei organtransplantierten Patienten
    Praxis (Bern 1994). 2012;18;101(2):75-83
  2. Mayer F, Hofbauer G, Nowak A
    Frühe kutane Karzinogenese bei organtransplantierten Patienten
    Praxis (Bern 1994). 2012;31;101(22):1401-9
  3. Nowak A, Krayenbühl P.-A
    Extraskelettale Vitamin-D-Wirkungen
    Leading Opinions 2013/2; 8-12
  4. Nowak A, L. Serra AL
    Abklärung der Proteinurie
    Praxis (Bern 1994). 2013 Jun 1;102(13):797-802
  5. Hakman P, Vallelian F, Nowak A
    Praxis (Bern 1994). 2013 Jun 5;102(12):703-8; quiz 709-10
  6. Müggler A, Iseli SM, Meindl-Fridez C, Nowak A, Brunckhorst CB
    Praxis (Bern 1994). 2013 Sept 1;102(19):1155-64
  7. Nowak A, Göhner K, Cohen C
    Caplan-Syndrom: eine untypische Differentialdiagnose des „pulmo-renalen“ Syndroms
    Praxis (Bern 1994). 2014 Feb 26;103(5):279-84
  8. Pollock E, Nowak A
    The cardio-renal problem
    Swiss Med Wkly. 2014 Dec 4;144:w14051. doi: 10.4414/smw.2014.14051
  9. Steinack C, Gaspert A, Kovacs R, Nowak A
    Morbus Fabry: Selten, aber nicht zu verpassen. CME
    Praxis (Bern 1994). 2015 Jul;104(14):719-29
  10. Rodieux F, Pfister M, van den Anker J, Rohrbach M, Schuknecht B, Gaspert A, Palla A, Nowak A
    Unexplained peripheral neuropathic pain and/or unexplained stroke in young patients – think about Fabry disease
    Swiss Archives of Neurology, Psychiatry and Psychotherapy 2016 Apr;167(3)74-80
  11. Schreiner F, Krayenbühl PA, Goede J, Nowak A
    Approach to the Patient with Elevated Serum Ferritin
    Praxis (Bern 1994). 2016 May 11;105(10):543-51
  12. Nowak A
    Linksherzhypertrophie – denken Sie an einen Morbus Fabry
    Cardiovascular Medicine. 2016;19(05)
  13. Krüger S, Nowak A, Lang K, Müller TC
    Case report on General anesthesia and Fabry disease
    A A Case Rep. 2017 May 15;8(10):247-249
  14. Battegay E, Cheetham M, Holzer BM, Nowak A, Schmidt D, Rampini S
    Multimorbiditätsmanagement im Alltagsdilemma
    Der Internist. 2017 DOI 10.1007/s00108-017-0200-9
  15. Lüthi L, Andreas Kistler A, Nowak A
    Hyperkaliämie bei Patienten mit chronischer Hämodialyse (exotische Ursache, lebensbedrohliche Folge)
    Praxis (Bern 1994). 2017 Jun;106(12):679
  16. Lecheler L, Richter M, Franzen DP, Rampini SK, Cheetham M, Jenewein J, Battegay E, Nowak A
    The frequent and underrecognized co-occurrence of Acute Exacerbated Chronic Obstructive Pulmonary Disease and Depression warrants screening: a systematic review
    Eur Respir Rev. 2017 Jun 14;26(144)


  1. Frederique Barbey, Albina Nowak
    Die Fabry Krankheit erklären. Von Ärzten für Kinder Verpasst! Medikidz 14 Basil Street, London 2017.